- CODEN : IAJPBB
- issn 2349-7750
TITLE:
ASSOCIATION OF BILIRUBIN WITH LIVER ENZYMES IN FALCIPARUM MALARIA AFFECTED PATIENTS
AUTHORS:
Sajeeda Latif Khan, Maryam Nazir, Muddasar Tahir
ABSTRACT:
Introduction: Malaria Falciparum is responsible for 1-3 million deaths annually worldwide. Liver involvement is common and can occur as high serum bilirubin, liver enlargement and high liver enzymes. It has been observed that unconjugated hyperbilirubinemia usually causes increased mortality. Alanine aminotransferase (SGPT) is an indicator of liver damage. This study was conducted to observe a correlation between liver enzymes and bilirubin in patients with Plasmodium falciparum malaria. Aim: To observe the correlation coefficient of bilirubin with liver enzymes (SGPT, SGOT and alkaline phosphatase) in patients with falciparum malaria. Study Design: A descriptive study Place and duration: In the Department of Pathology, Sir Gangaram Hospital, Lahore for one year duration from March 2019 to March 2020. Materials and methods: A total of 81 patients of different ages and both genders suffering from severe malaria were selected with non-probable sampling. Nine patients with hepatitis B and C infection were excluded from the study. Of the remaining 72 cases, 48 (70%) had Plasmodium falciparum infection and 24 (30%) had Plasmodium vivax infection. Falciparum infected patients were divided into two groups equally depending on the duration of the disease. In Group I; the disease continued for 1 to 7 days, in group II lasted for 8 to 20 days. Patients suffering from plasmodium vivax infection had a duration of 1 to 20 days and were placed in group III. Results: Group I, SGPT and alkaline phosphatase showed a statistically significant positive correlation with bilirubin (r = 0.50 and r = 0.054), and SGPT showed a perfectly positive correlation in group II (p <0.05). r = 0.88; P <0.01), SGOT and alkaline phosphatase also showed a statistically significant positive correlation. In group III, both transaminases and alkaline phosphatase showed a statistically significant positive correlation r = 0.82, 0.63 and 0.69, respectively. Conclusion: Positive correlation of liver enzymes and bilirubin suggests that liver function tests should be performed with early diagnosis of malaria infection Plasmodium falciparum to prevent complications and reduce mortality. Key words: malaria, liver enzymes, bilirubin, malaria falciparum
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Approved Journal
NLM ID:101711216 [Serial]
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ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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