- CODEN : IAJPBB
- issn 2349-7750
TITLE:
SEROPREVALENCE OF HEPATITIS C VIRUS IN LOCAL PEOPLE OF LAHORE DIVISION
AUTHORS:
Muhammad Khalid, Muhammad Usman Haider, Arshad Karim
ABSTRACT:
Objective: The hepatitis C virus is an important public health problem and is a leading etiological factor in chronic liver disease worldwide. Chronic hepatitis C virus infection is persistent and asymptomatic disease in humans can cause cirrhosis, fibrosis and hepatocellular carcinoma. This study was conducted to determine the prevalence of anti-HCV antibodies by ELISA in the general population of Lahore. Place and Duration: In the Medical departments of Mayo Hospital Lahore for one year duration from January 2019 to January 2020. Methods: A cross-sectional study was designed containing 2,800 serum samples from the general population in Lahore. Samples were analyzed for anti-HCV antibodies by enzyme-linked immunoassay (ELISA) and alanine aminotransferase (ALT) levels were also assessed for positive samples. The results were statistically analyzed using SPSS 16.0. The chi-square test and fishermen test was used to find a relationship between various variables such as age group, gender and area. Results: Of the 2,800 subjects, 1,872 men (66.8%) and 928 women (32.2%) were analyzed to detect anti-HCV antibodies. Among 2,800 people, 196 (7.0%) were positive for anti-HCV antibodies. A relationship between anti-HCV antibodies for sex and region was observed. There was no significant difference between ELISA and gender. Only anti-HCV antibodies in the 41-50 age group differed significantly in p-values (<0.05) in the ELISA. The highest average ALT (alanine aminotransferase) observed was 77.3 IU / L among 41-50 age group. Conclusions: In this study, we attempted to determine the incidence of anti-HCV antibodies in the general population in Lahore and concluded that the incidence of anti-HCV infection was 7% in the study population. We recommend routine testing for anti-HCV antibodies by ELISA, which can help reduce the transmission of HCV infection. Keyword: Seroprevalence, anti-HCV antibodies, ELISA, ALT,
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Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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