Dr Rabbia Rasheed, Dr Ghazala Muzaffar, Dr Azka Khan
Objectives: This research work carried out to find out the relationship between concentration of the serum copper and NTD (Neural Tube Defects) pregnancies in our region which is stated as a high prevalence region for NTDs. Methodology: This is a case control research work carried out on thirteen mothers with neonates present with NTDs and thirty-five mothers as healthy controls from the same region in the duration of June 2018 to November 2019. Spectrophotometer was in use for the measurement of copper in serum. Results: The level of serum copper in females present with newborns with NTDs and females with healthy neonates was 15.90 ± 6.10 micro-mol per liter and 15.20 ± 6.20 micro-mol per liter, correspondingly. Overall, 15.40% females in case-group and 25.70 % females in the group of healthy controls were present with deficiency of copper. Logistic regression analysis stated no relationship between the deficiency of copper and NTDs presence (OR= 0.50, 95.0% Cl: 0.050-3.20). Conclusion: The findings of this research work declared that there is no relation between the level of concentration of copper in serum and presence of NTDs (Neural Tube Defects). KEY WORDS: NTDs, serum, copper, deficiency, regression, analysis, controls, case-group, prevalence, measurement, pregnancy.