::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EFFICACY OF TREATMENT OF TINEA CAPITIS WITH GRISEOFULVIN INSTIGATED BY MICROSPORUM CANIS

AUTHORS:

Dr Ayesha Khan, Dr Sana Rafique, Muddassar Ghaffar Qureshi, Dr Haroon Zahoor, Muzzammil Ghaffar Qureshi, Dr Ammara Ghaffar, Dr Maida Ghaffar

ABSTRACT:

Background: Griseofulvin is an antifungal agent that has been successfully used in the treatment of dermatophyte-induced tinea capitis. Aim: Our goal was to assess the effectiveness of griseofulvin treatment in tinea capitis caused by the zoophilic species Microsporum canis. Place and Duration: In the Dermatology department of Mayo Hospital Lahore for six months duration from September 2019 to February 2020 Patients and methods: Nine mycologically confirmed cases of inflammatory and non-inflammatory tinea capitis were included in the study. Griseofulvin treatment was initiated 10 mg / kg once daily at night with milk for 8 weeks, and patients were followed up to 8 weeks after treatment. Results: Of 9 patients, 4 males and 5 females were included. Their age ranged from 6 to 12. The type of acute folliculitis was observed in five patients, and the type of gray patch was observed in four patients. Microsporum canis is an isolated pathogen in all cases. Griseofulvin was prescribed to patients. While clinical cure was observed in 89% of cases, mycological cure was observed in 100% at the final evaluation (8 weeks after treatment termination). Adverse events are few, minor and reversible. Conclusion: Griseofulvin has been found to be effective, well tolerated and safe treatment for tinea capitis caused by Microsporum canis. Key words: Griseofulvin, Tinea capitis, Microsporum canis.