- CODEN : IAJPBB
- issn 2349-7750
TITLE:
STUDY TO DETERMINE THE CLINICAL PRESENTATION OF CELIAC DISEASE IN CHILDREN
AUTHORS:
Dr Hamayon, Dr Zmeryalai, Dr Zahid ullah
ABSTRACT:
Aim: To assess the clinical features of celiac disease in children. Place and Duration: In the Pediatric Medicine department, Railway General Hospital, Rawalpindi for one year duration from February 2019 to February 2020. Materials and methods: We performed a retrospective analysis of data from 70 patients who underwent a small intestine biopsy (SBB) with suspected celiac disease. Forty-six children confirmed celiac disease based on the criteria of the European Society for Pediatric Gastroenterology & Nutrition (ESPGAN). 24 patients due to lack of observation, ambiguous response to a gluten-free diet (GFD) and non-specific histology were excluded from the study. Clinical signs and symptoms, anthropometry and laboratory tests were analyzed. Results: A total of 46 children with M: F = 1: 1.2 meet the diagnostic criteria for celiac disease. The mean age and onset of symptoms at diagnosis were 6.7 and 3.4 years, respectively. Chronic diarrhea, lack of development and pallor were the most common clinical symptoms occurring in 82.6%, 89% and 95.6% of children, respectively. Flatulence and clubbing were reported in 65.2% and 17.4% of patients. Four children who received rickets and three had swelling of the feet during a clinical trial. Weight and height <5th percentile occurred in 91.3% and 86.9% of patients, respectively. Hemoglobin <10 g / dl was found in 45 children and elevated ALT> 40 I.U. was present in 13 patients. Conclusion: Chronic diarrhea, poor growth and anemia are the three main clinical features in children with celiac disease. Diagnostic criteria must be met before determining celiac disease in a child because GFD is recommended for life. Key words: celiac disease, diarrhea, pallor, short stature, children
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Approved Journal
NLM ID:101711216 [Serial]
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ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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