Dr Sana Rafique, Muddassar Ghaffar Qureshi, Dr Ayesha Khan, Muzzammil Ghaffar Qureshi, Dr Haroon Zahoor, Dr Ammara Ghaffar, Dr Maida Ghaffar
Aim: To determine the role of N-acetylcysteine in the prevention of CIN in high-risk patients undergoing coronary angiography. Study design: A retrospective, observational study. Place and Duration: The study was conducted in the nephrology department of Lahore General Hospital Lahore for one year duration from March 2019 to March 2020. Methods: We reviewed the medical records of 120 patients over the age of 30 who underwent coronary angiography. All these patients were divided into two groups. Group A was given N-acetylcysteine, and patients in Group B were not given N-acetylcysteine. Acute Nephropathy caused by contrast was defined as an increase of at least 0.5 mg / dL serum creatinine from baseline to 48 hours after administration of the contrast agent. All data was collected in a previously designed form. The age was compared between the two groups using an independent t-test, and other parameters were analyzed using a Chi-square test. Results: There was a statistically significant difference between the two groups (group without N-acetylcysteine 17% and group N-acetylcysteine 3%, p = 0.029). Conclusion: Iopromidol, a nonionic, low osmolality contrast agent can induce acute contrast induced nephropathy in high risk patients which can be prevented by prophylactic oral administration of the antioxidant N-acetylcysteine, keeping all patients well hyrated/euvolemic. Key words: contrast induced nephropathy, N-acetylcysteine, Iopromidol.