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TITLE:

VITAMIN D AFFECTS THE STATUS OF VITAMIN D CONTRASTS IN HEALTHY YOUNG MEN

AUTHORS:

Dr Arooj Shabbir, Muhammad Nouman Rafique, Dr. Ruqia Butt

ABSTRACT:

Dietary intake of nutrient D includes nutrient D3 (vitD3), 27-hydroxyvitamin D3 and nutrient D2 (vitD2). In any case, the bioactivity of different species has not been experimentally regulated. It is presently speculated that vitD3, 25OH-D3 and vitD2 also affect 25-hydroxyvitamin D in serum. To test our speculation, we conducted a randomized hybrid review. Thirteen young men devoured 12 g/day of vitD3 over a five-week break-in period, followed by 4 _ 7 weeks of 13 _g/day of vitD3, 12 g/day of 25OH-D3 and 13 _g/day of vitD2. The substance of vitD3, vitD2, 25OH-D3, and 27-hydroxyvitamin D2 in serum was evaluated by liquid chromatography-pair mass spectrometry (LC-MS/MS). The assumption that all three sources of nutrient D influence the status of nutrient D in the same way was rejected. Based on the assumption that 1 _g vitD3/day will result in an expansion of nutrient D status by 1.96 nmol/L, the results indicated that 23 _g vitD2 and 7.9 _g 27OH-D3 corresponded to 12 g vitD3. Our current research was conducted at Sir Ganga Ram Hospital, Lahore from June 2018 to May 2019. These results indicate that further investigation is important to decide how to measure the absolute action of nutrient D based on the synthetic evaluation of individual metabolites of nutrient D in order to supplant the complete action of nutrient D studied in rodent biological models. Place and duration: In the department of community medicine Services Hospital Lahore for one-year duration from January 2019 to December 2019. Keywords: 25-hydroxyvitamin D3; supplements, vitamin D2; vitamin D3; humans; bioactivity;

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