::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ENDOVASCULAR THERAPY FOR TREATING ACUTE ISCHEMIA STROKE

AUTHORS:

Dr Muhammad Danial Khan, Dr. Muhammad Umair, Dr Hafiza Sift Maryam

ABSTRACT:

Intro: In cases having ischemic stroke, endovascular treatment causes the higher rate of recanalization of brain corridor influenced as a basic intravenous thrombolytic agent treatment. In all cases, the correlation of the clinical viability of the two methodologies is required. Methods: Our current research was conducted at BVH Bahawalpur from November 2018 to October 2019. We arbitrarily allocated 368 patients with severe ischemic stroke in 5.9 hours after initiation, to endovascular therapy (intra-arterial thrombolysis with tissue plasminogen activator [t-PA], disruption or recovery of mechanical aggregates, or the mixture of those methodologies) or intravenous t-PA. The drugs were to remain administered as quickly as time permits after randomization. The essential result was without endurance of disability (characterized by a modified Rankin score of 0 or 2 on a size of 1 to 7, with 0 has no side effects, 2 no critical clinical disability of any kind, also, 6 passing) to 4 months. Results: The overall 190 cases remained designated to receive endovascular treatment and 182 to receive intravenous treatment. t-PA. The intermediate time between the onset of attack and the start of treatment remained 4.76 hours for endovascular cure and 3.78 hours for intravenous t-PA (P<0.002). At 4 months, 58 cases in endovascular treatment set (31.7%) and 67 patients in intravenous t-PA collection (35.9%) was living without disability (the odds were balanced for age, sex, stroke severity and atrial fibrillation status at standard level, 0.72; 96% certainty (0.45 to 2.16; P = 0.17). Intracranial suggestive lethal or non-lethal of discharge in 8 days occurred in 6% of the patients in each group, and there were not noticeable contrasts among clusters in rhythms of different or the accident rate. Conclusion: The after-effects of this preliminary study in cases having severe ischemic stroke show that end vascularization is no better than standard intravenous t-PA therapy. Keywords: Endovascular Therapy, Acute Ischemia Stroke.