- CODEN : IAJPBB
- issn 2349-7750
TITLE:
POLYMERIC MICELLE AS A SMART DRUG CARRIER: A REVIEW
AUTHORS:
Hrutuja padge, Dr.Mrs Sudha Rathod, Dhanashree Devre, Akshay Gole
ABSTRACT:
One of the most widely needed study is related to the creation of Nano-sized molecule with well-defined structures and functionalities. These Nano molecular structures are generated as a result of self-assemblage of amphiphilic block polymers. Self-assembly of block polymers via hydrophobic and hydrophilic effects, electrostatic interactions, hydrogen bonding, and metal complexation has shown tremendous potential for creating such monomolecular structures with a wide range of applications. Polymeric micelles have gathered considerable attention in the field of drug and gene delivery due to their excellent biocompatibility, low toxicity, enhanced blood circulation time, and ability to solubilize a large number of drugs in their micellar core. Polymeric micelles have recently emerged as a novel promising colloidal carrier for the targeting of poorly water soluble and amphiphilic drugs. Polymeric micelles are considerably more stable than surfactant micelles and can solubilize substantial amounts of hydrophobic compounds in their inner core. Due to their hydrophilic shell and small size they sometimes exhibit prolonged circulation times in vivo and can accumulate in tumoral tissues. This review elaborate the chemical nature of polymeric micelles as well as the methods used to characterize them, Special emphasis is put on drug loading procedures, Potential medical applications. Polymeric micelles can be used as 'smart drug carriers' for targeting certain areas of the body by making them stimuli-sensitive or by attachment of a specific ligand molecule onto their surface. Keywords: Polymeric micelles, amphiphilic molecule, tumor targeting, self-assembly
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
Indexed In
S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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