K. Washid *, P. Bhavesh, G. Himanshu, S. K.Amit
Sulpha containing the drug are chemotherapeutic agents whose molecules contain a 4- amino benzenesulfonamide moiety. Due to low cost, low toxicity, and excellent activity against bacterial diseases, Sulphadiazine is among the most widely used as antibacterial agents. Sulfadiazine is a sulphanilamide derivative that is used as an antibacterial as well as an antimalarial drug. The Sulphadiazine were the first effective chemotherapeutic agents to be employed systematically treatment of infectious diseases remains an important and challenging problem because of a combination of factors including emerging infectious diseases and the increasing number of multi-drug resistant microbial pathogens..Some metals are essential for biological functions and are found in enzymes and cofactors required for various processes. For example, hemoglobin in red blood cells contains an iron porphyrin complex, which is employed for oxygen transport and storage within the body. Transition metal complexes have comprises of inorganic, Metallo-organic also as bio-inorganic elements because of their numerous applications in wide-ranging areas from material to biological sciences. the potent molecule must be the target within the body in sufficient concentration and stay there during a bioactive form for the expected biologic events to occur. The drug development process involves the moiety of drug during absorption, distribution, metabolism, and excretion (ADME) increasingly earlier within the preclinical studies, complex are numerous but access to the physical samples is limited. In that context, computer aided drug design constitute valid alternatives to experiments. Key words: Sulpha drugs,Charecterization, Swiss ADME, Antimicrobial Activities etc.