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ANALYSIS OF EFFECTS OF BLOOD PRESSURE IN IOP IN PRIMARY OPEN ANGLE GLAUCOMA

Dr Syed Dawar Hussain, Dr Quratulain, Dr Rabbia Afzal

Introduction: Glaucoma is commonly defined as optic neuropathy characterized by progressive loss of retinal ganglion cells (RGCs) which is associated with characteristic structural damage to the optic nerve and visual field loss. Aims and objectives: The basic aim of the study is to analyze the effects of blood pressure in IOP in primary open angle glaucoma. Material and methods: This study was conducted in the hospital of Skardu during 2018 with the permission of ethical committee of hospital. There were total 100 patients which were selected for this study. At enrollment, individuals were ≥50 years of age and were treated with antihypertensive medications for at least 1 year before the beginning of the study. Results: The data were collected from 100 selected patients. After adjusting for age, sex, diabetes, type of antihypertensive drug used and time since diagnosis and IOP, there was no direct relationship between values of SBP or MABP and occurrence of glaucoma. However, an increase of confirmed POAG probability was observed among patients with DBP >90 mmHg; patients with DBP values higher than 90 mmHg were 2.2 times more likely to have confirmed POAG (p-value: 0.08). The type of antihypertensive treatment did not modify the relationship between BP and POAG. Conclusion: It is concluded that increase in BP is associated with an elevated IOP, leading to increased risk of glaucoma. In addition, the microangiopathy of hypertension can result in end organ damage including the retina and optic nerve.

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