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BONE DENSITY IN PATIENTS WITH HEPATIC CIRRHOSIS & ITS CORRELATION WITH CHOLESTASIS AND GROWTH

Dr. Samiullah Khan, Dr. Faizan Ayyub, Dr. Bakhtawer Mehmood

Bone denisy and osteoporosis considered a typical complication of chronic liver disease from cholestatic conditions to autoimmune, alcoholic and post-hepatitic cirrhosis. Its aetiology may inadequately recognize and may also differ in various liver diseases. The majority of symptomatic bone diseases in patients specifically having liver disease tend to be presented only after liver transplantation when initial rapid bone loss triggers a high rate of fracturing the first postoperative year. Limited bone mass prior to after liver transplantation would be the primary risk factor for post-transplant fracturing and, consequently, its comprehending and administration are of leading significance. Optimum administration of post-transplant osteopenia involves concern of pre- and post-transplant aspects. DXA (Dualenergy X-ray absorptiometry) examination has been carried out in patients with intrahepatic cholestatic diseases. Dualenergy X-ray absorptiometry was carried out on patients aged >5 years (accordingly with native liver) and they are diagnosed with A1AT (alpha-1 antitrypsin deficiency), BASD (bile acid synthetic disorder), CIC (chronic intrahepatic cholestasis) and ALGS (Alagille syndrome). BMC (bone mineral content) and BMD (Bone mineral density) Z scores were considerably minimal in ALGS and in CIC, as compared with A1AT and BASD (P < 0.001). Accordingly, later the adjustment of anthropometric, bone deficits endured in CIC but was not specifically diagnoses in ALGS. In ALGS, height-adjusted and weight-adjusted subtotal BMD and BMC Z scores were negatively correlated with TB (P < 0.001) and SBA (P = 0.02). Chronic Intrahepatic Cholestasis patients revealed considerable bone deficits that endured later the adjustment for weight and height and noticeably did not correlate with cholestasis degree. On the other hand low “Bone Mineral Density” and “Bone Mineral Content” reference Z scores were explored and described by weaken growth. Anthropometrically adjusted DXA measures in ALGS correlate with markers of cholestasis and bone fracture history. Keywords: Bone Density; Hepatic Cirrhosis;

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