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TITLE:

A STUDY ON THE ASSESSMENT OF DIAGNOSTIC ACCURACY OF DIFFERENT BIOMARKERS FOR PROSTATE CANCER

AUTHORS:

Dr Kifayat Tariq, Dr Mehboob Ul Wahab, Dr Mohammad Ishtiaq, Dr Kamran Ahmed

ABSTRACT:

Objective: In this research study the use of prostate specific antigen (PSA) and it sub type (fPSA %) free fraction of total prostate specific antigen percent, (PSAD) prostate specific antigen density as a bio marker for prostate cancer (PCa) is discussed. This research study was conducted to find diagnostic tool in prostate cancer such that serum totals PSA, fPSA% & PSAD. In terms of their sensitivity, specificity and overall accuracy. Methodology: 50 patients of prostate cancer were admitted in Institute of kidney Diseases Hayatabad Medical Complex Peshawar from January 2017 to January 2019. To find out the ratio of PSA and fPSA% in serum we used ELISA (Enzyme linked immunosorbent assay) this kit is present anywhere in medical lab. Data related to volume of prostate which is determined by abdominal sonography were used to count prostate specific antigen density & histology of the surgically cut out prostatic organ was conducted for laboratory verification of PCa for a rest of patients. Diagnostic awareness, particularity & accuracy of serum total PSA, fPSA% and PSAD were counted by using basic formulae against microscopic examination of tissue. Results: Microscopic study of tissue showed that in 50 patients forty-one suffer from prostate cancer the mean age of patients were seventy-one.2┬▒ten.1 years old. In these forty-one patient nine cases are those who suffer from Nodular Hyperplasia of Prostate (NHP) with prostate-specific tumor markers of these patients were commonly in the normal ranges. The awareness, particularity and overall diagnoses accuracy for PCa of serum total PSA (at cut off value of greater than ten ng/ml) were eighty.480 percent, eighty eight.900 percent and eighty two percent for serum free PSA (at cut off value of less than twenty five percent), were ninety two.680 percent, seventy seven.800 percent & ninety percent & for PSA density (at a cut off value of greater than point fifteen ng/ ml/cm3), were initiate to be ninety percent eighty eight.900 percent & ninety percent individually. Microscopically, twenty-seven (sixty-five point forty-six), thirteen (thirty-one point seventy percent) & one (two.44percent) cases were divided as poorly separated, normally separated & strongly separated carcinoma individually & amazing superiority had very good interaction with all prostate-specific tumor markers. Conclusion: These outcomes stress that diverse prostate-specific tumor markers have great diagnostic prediction with fPSA% & PSA Density have normally best diagnostic accuracy as compare to serum tPSA for PCa. Key Words: Microscopically, Prostate-Specific, Interaction, Carcinoma, Diagnostic, Antigen, Biomarker.

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