ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

EFFECT OF USE IN THE DIET OF Α-LINOLEIC AND LINOLEIC ACIDS ON THE DEVELOPMENT OF ATHEROSCLEROSIS IN EXPERIMENTAL MICE

Ruslan Omarov, Ivan Gorlov, Marina Slozhenkina, Elena Zlobina, Natalia Mosolova, Sergei Shlykov

The article presents the results of the effect of modified beef on the progression of atherosclerosis. The type and amount of PUFAs that will be needed to overcome the potentially proatherosclerotic effect of saturated fatty acids in beef and the effectiveness of the action of n-3 PUFAs compared with n-6 PUFAs for normalizing lipid metabolism. To study the effect of enriched beef on the development of atherosclerosis in the experiment, we used live models of mice with artificially induced atherosclerosis, which allowed us to form a lipoprotein profile similar to that in humans. The effect of α-linolenic acid FLO on plasma lipids (lowering both cholesterol and triacylglycerol) suggests that such a diet may be more prophylactic of atherosclerosis than a diet rich in linoleic acid SO. However, the determination of the degree of atherosclerosis is not confirmed by the direct influence of the types of diets SO or FLO on a significant decrease in the area of damage. This suggests that these oils affect other factors than plasma lipids, which can affect the development of atherosclerosis. Keywords:polyunsaturated fatty acids, beef, atherosclerosis prevention, experimental mice.

FULL TEXT