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LIPID BASED DRUG DELIVERY SYSTEM – A REVIEW

Mounika Nandru*, Madhu Gudipati, S.S. Manikiran and Ramarao Nadendla

Lipid-based drug delivery systems (LBDDS) have gained significant attention in recent times, owing to their ability to overcome the challenges limiting the oral delivery of poorly water-soluble drugs. Despite the successful commercialization of several LBDDS products over the years, a large discrepancy exists between the number of poorly water-soluble drugs displaying optimal in-vivo performances and the application of LBDDS to mitigate their various delivery challenges. The formation of drugs carried out with the principle objective of enhancing their bioavailability. Poorly water-soluble drugs are challenging for the formulation scientists with regard to solubility and bioavailability. However, the number of applications for lipid-based formulations has expanded as the nature and type of active drugs under investigation have become more varied. This paper mainly focuses on novel lipidbased formulations, namely, emulsions, vesicular systems, and lipid particulate systems and their subcategories as well as on their prominent applications in pharmaceutical drug delivery. Key words: Lipid-based drug delivery systems, poorly water-soluble drugs, in-vivo.

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