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TITLE:

A STUDY ON THE LEVEL OF ANTIOXIDANTS IN 1 TO 5 YEARS OF CHILDREN SUFFERING FROM JAUNDICE

AUTHORS:

Nayab Maryam, Areen Shahid, Ayesha Abubakar

ABSTRACT:

Introduction: Phototherapy is the most widely used form of therapy for unconjugated hyper-bilirubinemia. Its noninvasive nature, easy availability, low cost and occurrence of few side effects have initially almost led to the assumption that it is innocuous. Jaundice is not a disease in itself. Objectives of the study: The main objective of the study is to find the level of antioxidant in children of age 1-5 years in Pakistan. Methodology of the study: The data was collected from Jinnah Hospital Lahore during January 2018 to November 2018. We collected the data from children of age 1 to 5 years who suffering from jaundice fever. 5cc blood was drawn from vein for the analysis of antioxidants from blood serum. We find the level of antioxidants, GSH, MDA, CAT and SOD in blood serum. Results: Serum MDA, GSH, GPx, Catalases and SOD concentrations were significantly lower after phototherapy than before it (p < 0.05). Conversely, serum TOS, lipid hydroperoxide levels were significantly lower than normal values. There were significantly positive correlations between serum total MDA and GSH. Conclusion: It is concluded that there is a positive correlation between jaundice fever in children and serum antioxidants level. Key words: Antioxidants, Level, Children, Fever.

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