ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

TITLE:

ANALYSIS OF OVULATION INDUCTION WITH METFORMIN VERSUS LETROZOLE IN FEMALES PRESENTING WITH POLYCYSTIC OVARIAN SYNDROME

AUTHORS:

Sardar Umer Rehman, Aasia Zehra, Ayesha Waheed

ABSTRACT:

Introduction: It was reported recently that Letrozole has good effects on endometrium, so it enhances rates of pregnancy after prospective ovulation induction for subjects suffering with PCOS. These beneficial advantages are lessened rate for occurrence of multiple pregnancies, no anti estrogenic adverse events, and consequently intensive monitoring is not much needed. Objectives of the study: The basic objective of the study was to analyze the ovulation induction with metformin versus letrozole in females presenting with polycystic ovarian syndrome. Methodology of the study: This cross-sectional study was conducted in Central Park Medical College during 2018. Total of 100 cases were enrolled by Non-Probability, consecutive Sampling. Woman age 18-39 years, BMI <35, Infertility due to anovulation, Polycystic Ovarian Syndrome. After taking Informed consent, the demographic information (name, age, contact, BMI) was noted. Then subjects were divided on random basis in two categories by utilizing lottery method. Females of both groups were counseled about dietary modification and encouraged to do brisk walk for 30 min twice a day. Results: In Group-A mean age of women was 28.18±6.58 years. In Group-B mean age of women was 27.08±5.15 years. In Group-A minimum and maximum age of women was 18 and 39 years while in Group-B this was 18 and 37 years respectively. As per body mass index criteria in Group-A 20(20%) women were having normal BMI, 44(44%) were overweight and 36(36%) were obese. In Group-B 20(20%) women were having normal weight, 59(59%) were overweight and 21(21%) were obese. Conclusion: It is concluded that letrozole plus metformin is more effective as therapy for the induction of ovulation in females presenting with polycystic ovarian syndrome as compared to letrozole alone.

FULL TEXT

Top
  • Follows us on
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.