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ANALYSIS OF EFFECT OF LEVOCARNITINE ON MUSCLE GLYCOGEN CONTENT IN TYPE 2 DIABETIC PATIENTS IN PAKISTAN

Aasia Zehra, Ayesha Waheed, Sardar Umer Rehman

Introduction: Glucose and lipid metabolism are inter related phenomenon in the human body. The number of people with T2DM is spiking worldwide, thus efficient management is required to improve the quality of life of diabetics. Objectives of the study: The main objective of the study is to analyze the Effect of Levocarnitine on Muscle Glycogen Content in Type 2 Diabetic patients in Pakistan. Material and methods: This case control study was conducted at Central Park Medical College during January 2017 to June 2017. Serum creatine phosphorkinase (CPK) levels were measured to exclude skeletal muscle disorder. There were 100 diabetic patients which were selected for this study. For this study we analyze the effect of levocarnitine on muscle glycogen content in type 2 diabetic patients. The data was collected through a detailed blood biochemical analysis. Fasting glucose levels were measured for further analysis. Results: Statistical analysis showed significant (p <0.001) increase in weight (268.40 ± 14.65 gm), fasting serum plasma glucose level (404.05 ± 59.65 mg/dl), fasting serum TG (132.17 ± 6.25mg/dl), fasting serum HDL (62.28 ± 1.25mg/dl) and TG:HDL ratio (2.12) due to high fat diet. The serum free carnitine was measured by terminal sampling and glycogen content of the EDL muscle of both groups were calculated. An increase in glycogen content was observed in in diabetic group (82.55±10.30 mg/100 gm muscle). Conclusion: It is concluded that Levo carnitine increases the glucose uptake by the skeletal muscle and hence improves the skeletal muscle glycogen stores in type 2 diabetes mellitus.

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