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TITLE:

VITAMIN D SUPPLEMENTATION PROTECT CHILDREN FROM LOWER RESPIRATORY TRACT INFECTION: A CONTROLLED TRIAL

AUTHORS:

Muhammad Arslan Anwar, Hafiza Hiba Anis, Mehwish, Muhammad Ahsan

ABSTRACT:

Background: Lower respiratory tract infections (LRTI) including pneumonia represent inflammatory conditions of the lungs i.e of the pleura, bronchioles, air-sacs and parenchyma.1 Objective: To determine the improvement in condition of children with lower respiratory infection with vitamin D supplementation Methods: Hundred pneumonia patients received antibiotics and vitamin D (100,000 IU) while another group of hundred patients received only antibiotics without vitamin supplementation. When respiratory distress settled, total days of treatment in the ward were calculated and patients were discharged. Each of these was kept under proper followed-up for 3 months after treatment to pick LRTI recurrence if any. Results: The mean recovery time for vitamin D group (5.7 +2.8 days) and non-vitamin D (6.1 +2.8 days) was almost same with P=0.29. But the frequency of repeated episodes of pneumonia within 30 days of treatment was lower in intervention group n=4 (2%) than the non-intervention group n=18 (9%) (P = 0.002). Conclusion: 100,000 IU of vitamin D given once during treatment of LRTI decreases the chances of recurrence in the next 30 days. Keywords: Vitamin D supplement, LRTI, Pneumonia, Vitamin D deficiency.

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