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TITLE:

IN VITRO EVALUATION OF THROMBOLYTIC ACTIVITY AND MEMBRANE STABILIZING ACTIVITY OF ETHANOLIC EXTRACT OF SYZYGIUM CUMINI LEAVES IN DIFFERENT DOSES.

AUTHORS:

Nisrat Jahan,

ABSTRACT:

Aims: In the present study, the The present study was commenced to judge ethnomedicinal worth of the plant Syzygium cumini (Family: Myrtaceae). Crude ethanolic extract of leaves was investigated for membrane stabilizing and thrombolytic activities. Place and Duration of Study: The study was carried out for 0ne year from July 2017 to August 2018 in the Department of Pharmacy, Southeast university, Dhaka-1216, Bangladesh. Methodology: In vitro membrane stabilizing activity was assessed by hypotonic solution and was compared with standard acetyl salicylic acid (ASA). In thrombolytic activity, percentage of inhibition of clot was carried out against Streptokinase. Results: Inhibition: Significant clot lysis were revealed by 2 mg & 4 mg of S. cumini by 29% (P<0.001) & 35.5% (P<0.001) where standard streptokinase shown maximum clot inhibition (70.5%) (P<0.001). Dose dependent ihibition in RBC rupture causing membrane stabilizing activity were 30.87% (P<0.01) & 45.71% (P<0.01) by 2 mg & 4 mg of plant extract where acetyl salicylic acid shown maximum inhibition by 82.75% (P<0.001). Conclusion: Leaves extract of the Syzygium cumini could be considered as potential source of compound(s) of thrombolytic and membrane stabilizing activities. The plant possesses significant bioactivities which rationalize it’s use as folk medicine.

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