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TITLE:

AN ASSESSMENT OF OVARIAN CANCER FEMALE PATIENTS’ DEATH AND SURVIVAL RATE AFTER SURGICAL INTERVENTION: NEOADJUVANT CHEMOTHERAPY VERSUS PRIMARY DEBULKING SURGERY

AUTHORS:

Dr Sidra Fatima, Dr. Mehwish Zulfiqar, Dr. Muhammad Usman Yousaf

ABSTRACT:

Objective: The main purpose of the study is to determine the survival and death rate of the female after surgical operation. This is determined by the two different methods of treatment between the females suffering from ovarian cancer. Methods: The study arranged was of a retroactive type and it was held at Mayo Hospital, Lahore from February to September 2017. The study was associated with the data obtained in 1999 and 2008 about the female’s treatment suffering from ovarian cancer. The clinical data obtained during the previous analysis was again studied and revised. And similar knowledge was obtained about the environmental, medical, therapeutically, pathological aspects of studies. Overall existence of patients was compared with growthfree existence. The comparison was made between patients who went either debulking surgery or neoadjuvant chemotherapy before surgery. Mathematical identification was performed by using SPSS. Results: Total 118 patients were undergone surgical cure. Out of which 66% gained the primary debulking surgery and rest of the 34% received neoadjuvant chemotherapy. The average age and tumour antigen 125 level before treatment was same. In the debulking group, two stages of patients were identified. That group had 94.8% patients with stage 3 carcinoma and 5.1% stage 4 carcinoma. While in other groups the percentage of patients in stage 3 and 4 were 80% and 20% correspondingly. The most favourable occurrence of debulking was 56.8% in the earlier group as compared to 79.4% in the second group. At the time of surgery, the total loss of blood was recorded as 1500 ml. The loss of blood was almost the same in the different exhaustive care unit. In addition to the loss of blood, the rate of urinary swathe, bowel grievance and bowel reactions were also analogous. The growth free existence was also comparable in both groups. Conclusion: Equivalent existence rates and peri-operative difficulties can be created by neo-adjuvant chemotherapy followed by intermission debulking. Keywords: Ovarian epithelial cancer, Chemotherapy, Gynecological surgical procedure, Survival analysis.

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