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STUDY TO KNOW THE ASSOCIATION BETWEEN ORAL SQUAMOUS CELL CARCINOMA AND SERUM LIPID PROFILE

Dr.Fatima Arshad, Dr.Muhammad Zeeshan Azam, Dr.Abrar Ul Haq

Alterations in plasma lipid profile have relation with various cancers and pre-cancerous conditions of the oral cavity. Low lipid levels serve as a marker and prognostic indicator for the early detection of pre-cancerous and cancerous oral diseases. Objective: The purpose of this study was to determine the changes in plasma lipid profile in patients with squamous cell carcinoma of the mouth (SCC). Study Design: An Observational Study. Place and Duration: In the Oral and Maxillofacial Surgery Department and in collaboration with Medicine Unit I of Nishter Hospital Multan for Six months duration from August 2018 to January 2019. Methods: 120 patients, 60 SCC and 60 healthy controls were included in the study. Low density lipoproteins (LDL), Very low density lipoproteins (VLDL), total cholesterol (TC), fasting plasma lipid profile including triglycerides (TG) and high density lipoproteins (HDL) were recorded with an automated analyzer. Obtained data were analyzed by independent 't' sample test. Results: When compared with the control group, a statistically significant decrease in total cholesterol was observed in plasma, TG, VLDL, HDL and LDL in patients with oral SCC. Conclusion: Low lipid levels associated with oral SCC suggest an inverse relationship between oral cancer and serum lipid profile. Reduction in lipid levels can be considered as a useful biochemical marker for early oral malignancy detection. Key words: oral carcinoma of squamous cells, lipids, biochemical marker.

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