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PROSPECTS OF USE OF FLUORESCENT MEDICAL TECHNOLOGIES IN DIAGNOSTICS OF INFLAMMATORY DISEASES IN OTORHINOLARYNGOLOGY

A. B. Timurzieva, M. T. Aleksandrov, G. N. Nikiforova, V.V. Borisov

To substantiate use of fluorescent medical technologies in diagnostics of inflammatory diseases in otorhinolaryngology a technology was applied which is based on phenomenon of autofluorescence of tissue und on effect of combinatory scattering of light (Raman effect) that allows to register individual molecular vibrations in crystal lattice of substances which are parts of the tissue being examined. In future this effect will allow to use the medical technology as a diagnostic one. During the research a probe radiation with wavelength of laser radiation 532 and 405 nm was used. Spectral characteristics of tissues were obtained by means of hardware-software complexes EnSpectr R532 and EnSpectr М405 for registration of indexes both in vivo and in vitro. In addition, the study presents data which have been obtained in respect of microflora of pathologic focus (palatine tonsils) in an inflammatory process in order to evaluate contribution of microbial factor to resulting indexes of spectral characteristics of a biologic object. Results of the study show a possibility to use fluorescent technologies not only for evaluation of metabolic, morphometric and functional indexes of tissue in vivo over time, but also for analysis of individual spectral data of microbial composition of a pathologic focus and for analysis of histologic features of tissue in vitro. Nowadays diagnostic potentials of optic technologies (including fluorescent ones) are actively studied. This study presents experience of use of the above mentioned technologies for substantiation of prospects of application and for determination of range of their clinic use in clinic ENT practice. Key words: fluorescence, sensitivity, specificity, noninvasive medical technology, quick diagnostics, Raman effect (effect of combinatory scattering of light), inflammatory diseases, otorhinolaryngology.

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