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A CASE CONTROL STUDY TO ESTABLISH THE CORRELATION BETWEEN ACS (ACURE CORONARY SYNDROME) WITH HYPERTENSION AND URIC ACID AT PIMS ISLAMABAD

Dr Arjumand Yar Iqbal, Dr. Humaira Shoukat, Dr Irfan Ali Choudary

Background: The self-sustaining factor associated with disorders related to heart is hypertension. For many years, this risk factor is not discussed. Objective: The objective of this study was to assess the connection between acute coronary syndrome (ACS) and high serum uric acid level. Subjects & Methods: The study was organized at PIMS Islamabad (September 2017 to August 2018). Total enrolled patients were 367. They were grouped into cases and controls. The number of controls was 174 and they do not have the acute coronary syndrome. The cases were 193 in total. The cases were identified with acute coronary syndrome. The identification was carried out by suitable inspections. Age, gender, smoking, cholesterol, hypertension, BMI, CDL, serum uric acid level, HDL, disease status of acute coronary syndrome and triglyceride are the variables considered in this research. All the cases and controls signed the written agreement. The high level of serum uric acid in males was more than seven mg/dl and more than six mg/dl in females. SPSS was used for data entry and assessment. Results: Total patients selected in this research were 367. The mean age of patients of the acute coronary syndrome was (52 ± 11) years; whereas, controls were of (47 ± 15) years. 193 patients were having coronary heart disorder; whereas, 174 controls were not having a coronary heart disorder. The number of males among patients of ACS is 84% and among controls, males were 75%. Among cases and controls, serum uric acid was (6.1 ± 1.2) mg/dl and (5.1 ± 0.3 mg/dl) respectively. In cases, LDL was (119 ± 37) mg/dl; whereas, in controls, LDL was (118 ± 32) mg/dl; triglyceride among patients and controls was (172.68 ± 98) md/dl and (168 ± 78) md/dl respectively; in patients of ACS, HDL was (41.92 ± 8) md/dl and (43 v 6) md/dl in controls; whereas, BMI was (27 ± 3) and (25 ± 6) in patients of ACS and controls respectively. As compare to 24% among Non-CHD patients, ACS patients have high serum uric acid (P-Value 0.00). Conclusion: It is concluded that acute coronary syndrome and increased serum uric acid level was significantly interlinked. Keywords: Acute Coronary Syndrome (ACS), Cases, Controls, BMI, Triglyceride, LDL and HDL.

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