Dr . Asma Ishfaq, Dr.Muhammad Farhan, Dr.Muhammad Irfanullah
Objective: To observe the effect of a single dose antibiotic, its efficacy as a 24-hour regimen to prevent SSIs in contaminated, elective surgical procedures and clean procedures. Study design: A randomized, prospective study. Place and Duration: In the Surgical Unit I of Jinnah Hospital Lahore for one year duration from September 2017 to September 2018. Methods: 208 total cases planned for general surgery were selected for the analysis. Into 2 groups, Patients were divided randomly. A single dose group were given ceftriaxone 2 grams intravenously, while the 24-hour group were given ceftriaxone 2 grams intravenously during anesthesia induction, followed by 8 and 16 hours of 1 g operation. Results: Ceftriaxone administration in a single-dose regimen was associated with a higher SSI ratio compared to the rates of patients receiving a 24-hour regimen (9.6%, 6.7%). Conclusion: In the case of clean contaminated and contaminated procedures, multiple prophylactic antibiotic doses should be used for 24 hours instead of the single dose in surgical prophylaxis. Key Words: Antibiotic prophylaxis, Surgical site infection (SSI).