::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

STUDY TO KNOW THE FREQUENCY OF HELICOBACTER PYLORI INFECTION IN PERFORATED PEPTIC ULCER PATIENTS

AUTHORS:

Dr . Asma Ishfaq, Dr.Muhammad Farhan, Dr.Muhammad Irfanullah

ABSTRACT:

Objective: To evaluate the Helicobacter pylori infection prevalence in perforated peptic ulcer patients. Study Design: A Prospective Study. Place and Duration: In the Surgical Unit II of Services Hospital Lahore for One year duration from August 2017 to August 2018. Methods: All subjects were evaluated for clinical examination, laboratory investigations and history. Data for abdominal and chest radiography, anti-H-Pylori serum, abdominal ultrasound, histopathology and biopsy, perforation and Helicobacter pylori infection were determined. Results: Perforated peptic ulcer cases were diagnosed in 75 patients during the study period. Men (73%) are more than women (27%). Most of the patients were over 30 years of age and 44.6 years SD ± 9.89 was the mean age. For Helicobacter pylori, serological test was positive in all 75 subjects; However, biopsy histopathology expose in 50 cases (66.6%) with H. pylori. In exploratory laparotomy, 25 (33%) patients had perforated gastric ulcer and 50 (67%) patients had perforated duodenal ulcer. Conclusion: The prevalence of perforated peptic ulcer on biopsy, one of the life-threatening complications of H. pylori, was 67% in this study. Key Words: Prevalence, Helicobacter pylori, perforated peptic ulcer.