- CODEN : IAJPBB
- issn 2349-7750
TITLE:
PREVALENCE OF VITAMIN D DEFICIENCY AND THERAPEUTIC ROLE OF VITAMIN D SUPPLEMENTS IN CHRONIC LIVER DISEASE
AUTHORS:
Kumayl Abbas Meghji, Muhammad Aslam Rind, Maria Nazeer Khyber, Tariq Feroz Memon, Muhammad Shahab Hanif, Muhammad Saqib baloch.
ABSTRACT:
Introduction: Vitamin D, along with its beneficial effects on bone, has many other advantages. There is rising concern in surveying the association between plasma vitamin D levels and chronic liver disease. Objectives: To ascertain the prevalence of vitamin D deficiency in patients suffering from chronic liver disease as well as to evaluate liver functionality and plasma vitamin D levels after vitamin D administration. Material and Methods: This was a two stage study. The first stage included evaluation of demographic and clinical data in 87 patients having chronic liver disease. The second stage included administration of various doses of vitamin D to patients having either insufficient or deficient plasma vitamin D levels. Post-experimental liver function tests and grades of liver functionality were assessed and compared with pre-experimental data. Results: 88% of the patients had either VD insufficiency or deficiency with a mean vitamin D level of 18.6 ± 9.28 ng/ml. Alcohol consumption contributed to a greater deficiency of vitamin D (p = 0.002). Mean vitamin D levels in patients with cirrhosis was 15.3 ng/ml, while non-cirrhotic patients had a mean level of 20.7 ng/ml. Liver functionality was found to be inversely correlated with plasma levels of vitamin D, Child A (16.17 ± 3.94 ng/mL) vs Child C (6.96 ± 5.64 ng/ mL). Normal values of VD levels were achieved in 92.7% of patients who did not have liver cirrhosis as compared to 88.4% of patients having liver cirrhosis. Serum Albumin levels (p < 0.05) and liver functionality grade (p < 0.05) also showed significant results. Keywords: Vitamin D, Chronic liver disease, CLD, Cirrhosis, Child-pugh, MELD
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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