- CODEN : IAJPBB
- issn 2349-7750
TITLE:
A SIMPLE UV-SPECTROPHOTOMETRIC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF CARVEDILOL IN BOTH BULK AND MARKETED DOSAGE FORM
AUTHORS:
Dr. A. Madhukar *, Juveriya Asrar , Mariyam , Adiba Sultana , Shehnaz Begum
ABSTRACT:
The present work was to develop two simple UV spectrophotometric methods for simultaneous estimation of Carvedilol (CAR) in bulk and tablet dosage form and validate as per ICH guidelines. In this method the absorption maxima was scanned from 200 – 400 nm and the λmax was found to be 248 nm was selected for analysis of Carvedilol. Linearity was observed in the concentration range 1-12μg/ml (r2 =0.9992) for the method. The % assay for the marketed formulation for absorption maxima and area under the curve method was found to be 100.69% and 100.82% respectively. The methods were validated with respect to linearity, precision and accuracy studies. Recovery studies for absorption maxima, and area under the curve was found to be 99.3% and 100.89% respectively. The developed methods were validated for linearity, precision, accuracy, LOD and LOQ as per ICH guidelines. The method was found to be linear within the conc. Range of 1-12μg/ml for Carvedilol. The present method was found to be simple, linear, precise, accurate and sensitive and can be used for routine quality control analysis for the estimation of furosemide in bulk and tablet dosage form. Keywords: Carvedilol (CAR), UV-Spectroscopy, Method Development, Validation and ICH guidelines.
FULL TEXT
Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
Indexed In
S.J Impact Factor:7.157
cosmos Impact Factor:4.153
ICMJE Recommendations
IP Indexing Impact Factor: 2.76
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