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AMLODIPINE AND NEBIVOLOL¬ - A REVIEW ON HPLC METHOD

Rajveer Bhaskar1, Monika Ola, Harshjeet Sisode*, Rakeshsing Rajput, Shailash Chalikwar

The review on focuses on recent analytical method development on HPLC high performance liquid chromatography Method for estimation on Amlodipine and nebivolol along with combination on both/other drug on hplc method development of drug dosage form. HPLC method can able to separate, detect, and quantify the various drug it can degradants that can from storage or manufacturing detect and quantify any drug and drug related impurities introduce during synthesis. It was separation techquine based on solid stationary phase and liquid mobile phase in theses system can various Advantages of HPLC system is pharmaceutical, clinical, ecological scientific etc. Validation can process of establishing characterization and limitation of method. Parameter of validation is Accuracy, Precision, Reputability, Intermediate precession, Linearity, Detection limit, Quantification limit, Specificity, Range, Robustness, System suitability determination, Force degradation study, Stability study. Amlodipine drug can use on high blood pressure coronary artery virus and category is calcium channel blocker, Angina pectoris. Side effect on dizziness, fatigue, headache, palpitations and nausea. It has been molecular weight is 506.06 g/mole. White powder, class 1st drug etc. nebivolol can vital hypertension disorder associate with endothelial dysfunctions and angina pectoris. It has been side effect on headache, dizziness, paresthesia, constipation, nausea, and diarrhea. It has been molecular weight is 405.435 g/mole white talc class 2nd drug. Keywords: HPLC techquine, Development and validation, stability study, Amlodipine, Nebivolol.

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