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TITLE:

GENES ASSOCIATION IN COLORECTAL CANCER

AUTHORS:

DR. ABDUL RAHEEM, DR. ZAHID HUSSAIN, MEHWISH

ABSTRACT:

Colorectal cancer now a days most common disease in the world many strategies have been under investigated for the treatment of colorectal cancer. Colorectal cancer undergoes metastasis and genes responsible for tumor suppressor genes. B catenin genes inhibition involves in the cancer. epithelial cells transformed in to the oncogenes. Mutation in the WNT pathway leading to the formation of lesion and these polyps leads in the formation of mutation in the epithelial cells. TCF family is the main predominant in the colorectal cancer. TCF 4 is the main precursor of this family. while TCF1 is the main dominant negative key precursor of this family. Keywords: Colorectal Cancer, B catenin genes, TCF family, HNPCC syndrome

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