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TITLE:

BIOLOGICAL EVALUATION OF STABILIZED WHEAT GERM IN HYPERCHOLESTEROLEMIA RATS

AUTHORS:

Maalem H. Al-Moalem

ABSTRACT:

There is a global rise in the prevalence of diseases such as atherosclerosis and cardiovascular diseases. Therefore, this study was performed to investigate the effect of feeding on stabilized wheat germ (SWG) at levels 25, 50,75 and 100% for casein in hypercholesterolemic (hyper-c) rats. Results showed that, replacing a (hyper-c) diet with (SWG) significantly reduced serum total cholesterol (T.C), total triglycerides (T.G), low density lipoproteins (LDL), very low density lipoproteins (v.LDL), while high density lipoproteins (HDL) increased .Furthermore, (hyper-c) diet with (SWG at levels 75 and 100% for casein) replacement also recorded the best and nearest of HDL-C to the (control–ve). Feeding on (hyper-c) diets substituted with SWG (G6 and G7) led to reduce the levels of serum liver function enzymes and increase the activity levels of antioxidant enzymes comparing with (hyper-c) control (G2) (control +ve). Histopathological examination showed that feeding diets supplemented with SWG to the hyper-c rats lowered the degree of liver lesions. So, it can be suggested that, SWG has a clear effect in lowering serum cholesterol levels and may be beneficial for patients with liver and cholesterol diseases. Keywords: Rats, lipid profile, stabilized wheat germ, Hypercholesterolemic

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