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NANO CARRIERS IN DETAIL: A REVIEW

Apoorva More and Akkshata Parab

To date, numerous nano-drug systems for different routes of administration have been evolved, including dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles. In particular, functionalized nano drug systems can offer modification of delivery time, provide targeted delivery to specific tissues and enhance in vivo solubility and thus the bioavailability of poorly soluble drugs. Thus, nano-drug systems could reduce the administration frequency while offering maximized pharmacological effects and minimizing systemic side effects, leading to better therapeutic efficiency and clinical results. More attention has been placed over past few years on lipid-based drug delivery system to overcome some limitations of conventional formulations. Promising delivery systems include solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). The purpose of this paper is to review the overall nano-drug systems information which includes the reasons to choose nano carriers, along with composition / ingredients, preparation method, characterization method, advantages and limitations of SLNs and NLCs as nano carriers. Keywords: Nano carriers, solid lipid nanoparticles, nanostructured lipid carriers, composition, preparation methods, characterization methods