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ANALYSIS OF THE INTRACELLULAR KILLING OF THE PERIPHERAL BLOOD NEUTROPHILLS IN PATIENTS OF B THALASEMIA MAJOR

Dr Arwa Shahzad, Dr Huma Tariq, Dr Mohammad Hamza Kiyani

Aim: This study aimed to study the peripheral blood neutrophils intracellular killing in patients of b- thalassemia major. Place and Duration: In the Department of Pathology, Mayo Hospital Lahore for one year duration from March 2019 to March 5, 2020. Methods: 60 patients with Β thalassemia were examined. Their age ranged from two to 20 years. The group consisted of 24 girls and 36 boys. The Candida intracellular killing and NBT (nitroblue tetrazolium) were performed in peripheral blood neutrophils of these patients. The average intracellular killing test results were within the normal range for patients, but showed a significant decrease compared with the results of normal control tests (60 normal individuals in the same age group were considered normal control. The reduction in the number of patients is significant who had splenectomy. An inverse relationship was observed between the results of intracellular death and serum ferritin level and age. Results: Average results of the patients' NBT tests showed an increase in comparison with those of the control group. The average results of patients whose spleens were removed due to hypersplenism are the same as those of ordinary spleens and are not associated with serum ferritin levels, but have a moderate relationship with the age of patients. Conclusion: One suggestion that can be made is the possibility of intracellular death of peripheral blood neutrophils in patients with B thalassemia to help identify the most susceptible to infection.