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TITLE:

ANALYSIS OF MIGRAINE POLYGENIC RISK SCORE ASSOCIATES WITH EFFICACY OF MIGRAINE-SPECIFIC DRUGS

AUTHORS:

Dr Muhammad Wajih Ansari, Dr Azhan Jamal Bukhari, Dr Faiza Ahmed, Dr Iqra Moatter Nurie, Dr Mohammad Raza Mehdi, Dr Ali Sattar

ABSTRACT:

Introduction: Migraine is a prevalent and disabling disease with an incompletely understood etiopathology. Aims and objectives: The basic aim of the study is to analyse the migraine polygenic risk score associates with efficacy of migraine-specific drugs. Material and methods: This descriptive study was conducted in Baqai Medical University, Karachi during August 2019 till December 2019. The data was collected with the permission of ethical committee of hospital. The data was collected through a qualitative method. All patients with migraine were interviewed face to face or by telephone by a trained physician or trained senior medical student using a semi-structured interview. The semistructured interview included questions covering the necessary clinical data for migraine diagnoses and information on the effect of migraine treatment. Results: The data consisting of 200 patients. The male:female ratio in patients with migraine was 1:4.7; this was slightly lower in MO (1:5.8) than in MA (1:3.8) (p = 2.7 × 10−4). The patients with migraine were on average 44.2 years old with an SD of 12.8. There was no significant difference in age (SD) between MO and MA (44.0 [12.1] years and 44.4 [13.6] years, respectively). A higher response rate was found for MO than MA in acute and prophylactic treatment response. Conclusion: It is concluded that PRS may be useful in the investigation of shared genetic risk with comorbidities, in studying the relation between primary headache disorders and their sub-forms, and to personalize migraine treatment.

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