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ANALYSIS OF ROLE OF VITAMIN D AT URINARY LEVEL AS A NEW BIOMARKER IN ANALYSIS OF DIABETIC NEPHROPATHY IN PAKISTAN

Dr. Muhammad Haroon Ghous, Dr. Sikander Afzal, Prof. Dr. Shahid Mahmud Malik, Prof. Dr. Farrukh Iqbal

Introduction: Diabetes mellitus (DM) belongs to a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Early detection of diabetic nephropathy (DN) represents a great challenge in an attempt to reduce the burden of chronic kidney diseases in diabetic patients. Objectives: The main objective of our study is the role of vitamin D at urinary level as a new biomarker in analysis of diabetic nephropathy in Pakistan. Methodology of the study: The study was conducted at Department of Urology, UCM, University of Lahore during 2018 to 2019. For the purpose of study 80 patients were selected and we collect the data from these selected patients. Furthermore the analysis of Urine, creatine, Albumin and other series of test were taken place in the pathology laboratory of the hospital. Results: Vitamin D levels were significantly elevated in micro- and macroalbuminuria patient groups compared with those of the normoalbuminuria patient group and controls. There was significant correlation between serum and urinary levels of VDBP in total patient group. Conclusion: These investigations shall be helpful in assessing the biochemical alterations in the Pakistani diabetic population, which should contribute to the development of treatment plans for this disease which is one of the most widely occurring and debilitating diseases. Key words: Albumin, Diabetic, nephropathy, disease, patients