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TITLE:

A COMPARATIVE ANALYSIS OF EFFICACY FOR TOCOLYSIS OF PRETERM LABOUR BETWEEN NIFEDIPINE AND MAGNESIUM SULPHATE

AUTHORS:

Dr Ali Husnain, Dr Nimra Imtiaz, Dr Maham Wajid

ABSTRACT:

Objective: The objective of this research was to weigh the effectiveness of nifedipine and magnesium sulphate for tocolysis of preterm labour. Materials & Methods: We completed this comparative research in the timeframe of November 2018 to September 2019 at Services Hospital, Lahore on a total of 182 patients. These patients were categorized as preterm labour patients. The age bracket of the patients was from 16 years to 35 years. LMP evaluated gestational age was (28 – 36) weeks with a singleton pregnancy. We did not include any patients under the age of 16 years and above the age of 35 years along with those patients who presented history of pre-eclampsia, diabetes mellitus, hepatic dysfunction, cardiac disease, severe IUGR, membranes rupture, antepartum haemorrhage, fetal distress, cervix (> 4 cm) dilated, chorioamnionitis, congenital fetal malformations, multiple pregnancies, nifedipine allergic and Salbutamol allergic. Results: In the age bracket of (16 – 35) years the mean age of Group I & II was respectively (24.66 ± 4.35) years and (23.98 ± 4.05) years (P-Value < 0.05). Group-wise mean gestational age was (32.65 ± 3.71) weeks and (33.21 ± 3.31) weeks respectively for Group I & II (P-Value < 0.05). There were 81 cases of uterine contractions cessation (89.01%) and 10 cases of no cessation (10.99%) in Group – I; whereas, for Group – II, 68 patients (74.73%) and 23 patients (25.27%) respectively. Therefore, Group I & II showed respective efficacy of 89.01% (magnesium sulfate) and 74.73% (oral nifedipine) (P-Value = 0.0124). Conclusion: The outcomes show that higher efficacy can be obtained through magnesium sulfate (89.1%) for preterm labour (acute tocolysis) than oral nifedipine. Keywords: Uterine Contractions, Tocolytic Agents, Preterm Birth, Magnesium Sulfate and Oral Nifedipine.

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