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Raees Ahmad, Dengfeng Ren, Fuxing Zhao, Xinyue Yuan, Fangchao Zheng, Xingfa Huo, Jinming Li, Muhammad Ali, Jiuda Zhao


Background: Hepatoid Adenocarcinoma of lung (HAL) is very rare and aggressive malignant tumor originated in the lungs. The exact features of the disease are still unclear because very less data available about this disease.We conduct this SEER (surveillance epidemiology and end result) database to illuminate the characteristics overall survival (OS) and prognosis of HAL. Materials and Method: We obtained this data from the SEER database between the year 2010 - 2015. Patient demographic and disease information statistics was compared by using the pearson chi-square test and binary logistic regression. Propensity score matching (PSM) was performed using the package in R, version 3.3.1 (R Foundation). Results: In unmatched data we have hepatoid adenocarcinoma of the lung (HAC) 42 patients and adenocarcinoma of the lung (AC) 111426 patients. In matched data we have HAC 42 patients and AC 208 Patients and following are the results. In the unmatched data there are some imbalances in the certain characteristics such as age at diagnosis, year of diagnosis, grade and surgery, there is no imbalances in the matched data. The estimated OS time before propensity score matching (PSM) in HAC of the lung is 4 months and AC of the lung is 13 months, and the estimated OS time after PSM in HAC of the lung is also 4 months while AC of the lung is 9 months. Conclusion: Most of the HAC of the lung patients present in the advance age, the gender ratio is almost same, the OS of the disease before PSM and after PSM is very poor. Key words: Lung Cancer; Hepatoid Adenocarcinoma; Overall Survival

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