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Dr. Shafi Muhammad Khuhawar, Dr. Shahid Hussain Memon, Dr. Mona Humaira, Dr. Asim Munir Memon, *Dr. Samar Raza, Dr. Rabail Memon


Objective: To determine the cardiac biomarkers in patients with acute pulmonary embolism. Patients And Methods: The two year cross sectional multidisciplinary and multicenter study (2015-2017) was conducted at tertiary care hospital while the data was also recruited from few private hospitals as well. All the patients diagnosed as cases of pulmonary embolism were explored to have detail history, clinical examination and along with routine investigations had transthoracic echocardiography (TTE) to detect right ventricular dysfunction. Venous plasma and serum samples were obtained on admission and serum cTnT levels were determined with the use of a commercial kit while plasma concentrations of H-FABP and NT-proBNP were measured qualitatively using a commercial enzyme-linked immunosorbent assay (ELISA) whereas the frequency / percentages (%) and means ±SD computed for study variables. Results: During two year study period total fifty patients were explored and study. The mean ± SD for age (yrs) of population was 49.21±7.54 while the mean ± SD for cardiac biomarkers detected as HFABP (ng/mL) 1.9±0.7 NT-proBNP (pg/mL) 183.3±56.4, cTn-T (ng/mL) 0.10±0.8, myoglobin, (ng/mL) 69.6±87.9, CK-MB (ng/mL) 12.1±8.9 and CRP (mg/dL) 6.1±5.3 respectively. Conclusion: The highest concentrations of HFABP, NT-proBNP, and cTn-T were observed in patients with PE. Keywords: Cardiac biomarkers and pulmonary embolism

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