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SICK SINUS SYNDROME AND ASSOCIATION WITH MICRO RNA1976 MYH6 AND SCN10A GENE

Aqib Bilal, Ren Ming

Sick sinus syndrome is a leading cause of hospitalization, especially for people over 70 years old. Acute and intensive care nurses play a significant role in supporting patients in cardiac control units with the diagnosis and treatment. The medical care of patients with sick syndrome consists of careful cardiac observation, monitoring of symptoms and correlation of these symptoms with signs of ECG and providing advanced cardiac life support if necessary. Sick sinus syndrome contains anomalies of the sinus node (SAN) and atrial muscle cells resulting in various arrhythmias, such as sinus bradycardia, sinus pauses, sinus arrest, and sinoatrial exit block. Sick Sinus Syndrome has a strong association with Micro RNA 1976 as it targets the channels Cav1.2 and Cav1.3 Ca2 + that result in sinus node dysfunction .The level of microRNA1976 in the plasma of SSS patients is up-regulated as compared to healthy person. Moreover, the novel MYH6 mutation delE933 causes structural damage to the sarcomere as well as functional impairments which results in the sinus node dysfunction and causes familial SSS. Similarly, the SCN10A gene's genotype AA is associated with a predisposition to the development of Idiopathic Sick Sinus Syndrome. In addition this genotype occurred substantially among men with SSS as compared to the control group. Keywords: Sick Sinus Syndrome, Gene, Micro RNA 1976, MYH6, SCN10A, Sinoatrial exit block