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REVIEW THE ANNOTATION OF C1236T MONO-NUCLEOTIDE POLYMORPHISM OF ABCB1 GENE ALONG WITH NON-RECEPTIVENESS TOWARDS ANTIEMETIC HANDLING IN VICTIMS BEFORE SURGERY

Dr. Tehreem Tariq, Dr. Ujala Ihsan, Dr Usman Jabir Sukhera

Objective: Purpose is to review the annotation of C1236T mono-nucleotide polymorphism of ABCB1 gene along with non-receptiveness towards antiemetic handling in victims before surgery. Methods: Respective medical test was held at Sir Ganga Ram Hospital in Lahore during 2017-18, consisted of victims suffering laparoscopic cholecystectomy. All the victims were provided with dosage of 0.1 mg/kg ondansetron intravenously about half an hour prior to the termination of operation and illustrations for Deoxyribonucleic acid were performed. The regularities of genetic material for mono nucleotide polymorphism were evaluated through the use of PCR along with RFLP. Results: Among a total of 426 victims, 201(47%) showed resistance against nausea or vomiting, while 225(52.8%) were affected by the disease. Evidence of nausea and vomiting after 2 hours from surgery were rare in victims having relation with 1236TT as compared to 1236(probability <0.001). Victims of CC inheritance showed huge evidence as compared to others i.e. p < 0.001. Conclusion: To expect reaction towards ondansetron Polymorphism of ABCB1 gene plays an important role. Keywords: ATP-binding cassette subfamily B member 1 (ABCB1), Single nucleotide polymorphism, Genotyping, Ondansetron, P-glycoprotein.

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