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ANTI-NOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF ETHANOLIC EXTRACT OF XYLOCARPUS GRANATUM LEAVES

Ekramul Hasan, Rajbongshi Lata, Abdur Rouf, Howlader Saurav*

Xylocarpus granatum (Family: Meliaceae) is a mangrove tree species used as herbal remedy for various ailments. But the scientific basis for its medicinal use especially in pain andinflammation remains unknown. Therefore, the present study was aimed toinvestigate the anti-nociceptive and anti-inflammatory effects of the leaves of Xylocarpus granatum in laboratory animals. The anti-nociceptive effect was assessed in mice using acetic acid-induced writhing, formalin-induced paw licking and tail immersion assays. Anti-inflammatory activity was evaluated on carrageenan induced paw oedema in rats. In acetic acid-induced writhing test, the extract at different doses (50 and 100 mg/kg) significantly (p <0.001) and dose-dependently reduced pain by 49.30 and 68.20%, respectively. The extract also significantly inhibited both the early and late phases of formalin-induced paw licking in mice. In the tail immersion test, the extract caused a significant inhibition of pain (68.91% inhibition, after 4 hr.) at a dose of 100 mg/kg. X. granatum caused a significant inhibition of paw oedema development in the carrageenan-induced oedema tests. The findings of the study suggested that X. granatum leaves have significant anti-nociceptive and anti-inflammatory effects, confirming the traditional use of this plant in the treatment of various diseases associated with pain and inflammation. Key words: Xylocarpusgranatum, anti-nociceptive, anti-inflammatory.

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