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TITLE:

EFFECT OF HELICOBACTER PYLORI ERADICATION THERAPY ON RELIEF OF CHRONIC IDIOPATHIC UTRICARIA SYMPTOMS

AUTHORS:

Dr Muhammad Khurram Shahzad, Dr Raheel Tahir, Dr Danish Hassnain

ABSTRACT:

Objective: To know the relationship between H. pylori infection and chronic idiopathic urticaria and to observe the eradication therapy effects. Study design: An observational study. Place and duration: In the Dermatology department of Nishtar Hospital Multan in collaboration with pharmacology department for one year duration from November 2017 to November 2018. Methods: Twenty patients with previous chronic idiopathic urticaria history were selected for the study. Serological tests were performed to determine the H. pylori infection presence and eradication treatment (Metronidazole 400 mg t.d.s, Clarithromycin 500 mg b.i.d and Esomeprazole 40 mg o.d) was given for 2 weeks. Clinical evaluation was performed on days 0, 1 month, 2 month, 3 month and 4 months using a scoring system (symptom rating scale). The current status of H. pylori was re-evaluated at 60 days to confirm any recurrence of symptoms and the efficacy of eradication therapy. Results: In 19 of 20 patients, H. pylori infection was found positive and eradication treatment was given. In 18 patients, Eradication therapy was successful, 1 subject has not complete the study and one patient had recurrence. At day 0, Mean SES scores were 3.73 ± 0.45, 2.52 ± 0.51 at 30 days, 1.52 ± 0.51 at 60 days, 1.15 ± 0.51 at 90 days and 0.47 ± 0.77 at 90 days. day 120. A change of 59.13 percent at p <0.002 was observed. Conclusion: H. pylori infection has a possible role in the chronic idiopathic urticaria pathogenesis. Key Words: Chronic idiopathic urticaria (CIU), Symptom Assessment Scale (SES), Helicobacter Pylori (H. pylori, HP).

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