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FREQUENCY OF DRUG RESISTNCE OF BACTERIA IN THE INFECCTION OF LOWER RESPIRATORY TRACT

Dr. Rida Shahzad, Dr Hurrain Malik, Dr Eesha Sattar

Objective: Infection of bacteria is very significant reason to make the violent condition of COPD (Chronic Obstructive Pulmonary Disease). The resistance to antibiotic have raised in the main causative agents of the diseases. The aim of this study is to interrogate the prevalence of antibiotic resistance among the isolates of bacteria in the infection of lower respiratory tract. Methodology: This was a transverse research work conducted in Allied Hospital Faisalabad. We gathered the protected samples of brush from the lower tract of respiration with the help of bronchoscopy in the admitted & ambulatory fifty-four chronic obstructive pulmonary disease patients with adverse state. Broth micro-dilution test was in use for the determination six anti-microbial agents isolated in vitro condition. Results: Among the isolates of s. pneumonia, 5.90% & 94.10% were moderate and severe grade resistant to penicillin & ampicillin correspondingly. Total 58.80% isolates were available with the resistance to erythromycin. The isolates of H. influenza were showing the hundred percent resistance to penicillin & ampicillin. Conclusion: The part of antibiotics is very important in the treatment of chronic obstructive pulmonary diseases signifying that every attempt should be in action to protect the antibiotic’s sensitivity with appropriate and timely use of these antibiotic. KEYWORDS: Lower Respiratory Tract, Isolates, Resistance, Penicillin, Influenza, Sensitivity, Appropriate, Chronic, Bronchoscopy, Broth, Obstructive.

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