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TITLE:

THE ROLE OF DAMAGES AND EPIGENETIC MODIFICATIONS OF DNA IN ALZHEIMER'S DISEASE

AUTHORS:

F. H. ZAKIROV, A. A. KRASILNIKOV, V. N. PUSHKINA, I. N. GERNET, L.B. ANDRUSCHENKO, G.A. YAMALETDINOVA

ABSTRACT:

Today, Alzheimer's disease is a progressive and common neurodegenerative disease. The active study of this pathology reveals more and more mechanisms of its development. Currently, there is a large amount of evidence that the processes of neurodegeneration are caused by damage tothe genetic apparatus of the cell, as well as its epigenetic modifications. This article discusses the main causes of changes in the structure of DNA in nerve cells and analyzes their participation in the pathogenesis of Alzheimer's disease. Keywords: Alzheimer's disease, neurodegeneration, DNA damage, mutations, oxidative stress, repair, epigenetics.

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