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TITLE:

ANALYSIS OF EFFECT OF VITAMIN D SUPPLEMENTATION IN POLYCYSTIC OVARY SYNDROME (PCOS) IN PAKISTANI ENVIRONMENT

AUTHORS:

Dr Ayesha Shafaq, Dr. Momina Masud, Dr Shahjahan Anwar

ABSTRACT:

Introduction: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder, affecting approximately 4%–18% women of reproductive age. It is a heterogeneous androgen excess disorder with different degrees of reproductive and metabolic dysfunctions. Aims and objectives: The main objective of the study is to analyse the effect of Vitamin D Supplementation in Polycystic Ovary Syndrome (PCOS) in Pakistani environment. Material and methods: This cross sectional study was conducted in Mayo Hospital Lahore during March 2018 to December 2018. This study was done with the permission of ethical committee of hospital. The data was collected from 100 female patients who were suffering from PCOS. Venous blood samples were drawn at examination and stored at −80°C after centrifugation at 3000 rpm for 10 min at 20°C. Results: The data was collected from 100 female patients who were suffering from PCOS. The mean age was 34 ± 5.05 years with a median BMI of 25.2 (22.0–30.4 kg/m2) and 24.0 (22.0–27.0 kg/m2). Overall median serum 25(OH)D was 49.0 (27.1–74.1 nmol/l) in PCOS versus 64.5 (39.2–85.7) in the control women. A severe vitamin D deficiency was present in 136 (21%) women out of 639 PCOS women, 190 (30%) women had a serum 25(OH)D between 25.1 and 50.0 nmol/l, 165 (26%) women had a serum 25(OH)D between 50.1 and 75.0 nmol/l, and 148 (23%) women had a serum 25(OH)D > 75 nmol/l. onclusion: It is concluded that there is a significant association between vitamin D status and metabolic disturbances in patients with PCOS. Moreover, PCOS women had a significant lower serum 25(OH)D compared to fertile controls

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