ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

ANALYSIS OF FREQUENCY OF PRIMARY HYPERALDOSTERONISM IN HYPERTENSIVE PATIENTS

Muhammad Aftab Saleem, Najam ul Hassan, Asia Zafar

Introduction: Primary hyperaldosteronism (Conn’s syndrome) has come to be viewed as the most frequent cause of secondary hypertension; according to recent studies it is found in 5% to 12% of patients with high blood pressure. Aims and objectives: The basic aim of the study is to analyse the frequency of primary hyperaldosteronism in hypertensive patients. Material and methods: This cross sectional study was conducted in Health care department, Punjab during March 2018 to September 2018. This study was done with the permission of ethical committee of hospital. The data was collected from 100 hypertensive patients. The diagnosis of hypertension was confirmed by ambulatory 24-hour blood pressure measurement or by three high blood pressure records (>140/90). The patients’ medical history was recorded, including heredity, current medication, and diseases. A physical examination of the patient was performed by the attending physician. Results: The data were collected from 100 patients. There were no significant differences in medical history, blood pressure, or measured biochemical variables between patients with a positive or negative fludrocortisone suppression test. Three patients were diagnosed with aldosterone producing adenoma (APA) and eight patients with bilateral adrenal hyperplasia (BAH). Compared with patients with essential hypertension, patients with primary aldosteronism had lower potassium (p = 0.003), higher SAC (p < 0.005), and lower PRC (p < 0.001) on both screening occasions. Conclusion: It is concluded that the ARR could be used as a screening tool for PA in newly diagnosed patients with hypertension, although the possibility to diagnose patients can be expected to be higher in selected patient groups.

FULL TEXT