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TITLE:

A RESEARCH STUDY TO COMPARE THE EFFECTIVENESS OF VERAPAMIL AND INTRAVENOUS ADENOSINE IN ACUTE PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA

AUTHORS:

Dr. Saba Sabahat, Dr. Nida-e-Farah, Dr. Merab Ahsan

ABSTRACT:

Background: The most frequently observed arrhythmia is the severe convulsive supraventricular tachycardia. The antibiotics used initially after the letdown of vagal manoeuvres adenosine to lapse severe PSVT. The antibiotics can be selected on the basis of their prices, need of action and contraindication. Objective: The main purpose of the study was to compare the effectiveness of intravenous adenosine and verapamil to transform a severe section of paroxysmal supraventricular tachycardia into the sinus rhythm. Subjects and Methods: The investigational study was arranged in Jinnah Hospital, Lahore (August 2017 to March 2018). The 200 patients suffering from severe PSVT present in the ICU were added in the study. A dose of 6 mg adenosine 4 boluses was given to the patients added in Group A. Then the dose of 12 mg 4 boluses was given to a similar group of patients. The second option is applicable when the PSVT was not reversed. Verapamil 5 mg was given to the patients present in Group B. Continuous dosage of 5 mg verapamil was given to the patients with the break of about 5 minutes unless complete success was achieved. The time required to rebuild the sinus rhythm from the execution of antibiotics in the body was recorded. The patients were also undergone ECG. ECG was performed on patients prior to and 15 minutes later to the cure. When the treatment was not completed by PSVT, patients were treated with the incorporation of verapamil in Group A. Results: The age limits of the patients present in Group A were between (42.8 ± 13.9) years. The age of Group B was about (40.5 ± 15) years. The presence of males is slightly greater in group A which was 58%. In group B the males were lesser in number about 49%. The achievement rate was 96% and 95% accordingly. The first dose of adenosine was found to be more successive in finishing PSVT. It was noticed that the adenosine take less time to perform its function than verapamil. The difference was (2.1 ± 2.7) to (5.1 ± 3.5) minutes. Conclusion: The success rate of adenosine and verapamil is almost equal but the speed was different in both cases. The 12 mg doses of adenosine act rapidly and efficiently and remove the severe segments of paroxysmal supraventricular tachycardia. Keywords: Paroxysmal supraventricular tachycardia, Adenosine, Verapamil, Vagal maneuvers.

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