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EFFECT OF LETROZOLE FOR OVULATION INDUCTION IN POLYCYSTIC OVARY SYNDROME IN FEMALE POPULATION

Dr Tahira Bashir, Dr Hina Shahab, Dr Amber Farid Awan

Introduction: Polycystic ovary syndrome (PCOS) is an endocrine and reproductive disorder with a prevalence ranging from 5% to 13% in women of reproductive age. Aims and objectives: The main objective of the study is to analyze the effect of Letrozole for Ovulation Induction in Polycystic Ovary Syndrome in female population. Material and methods: This cross sectional study was conducted in DHQ hospital, Narowal during March 2018 to December 2018. The data was collected from 100 female patients who visited the OPD of the hospital during their diseases. All those female who were suffering from PCOS, included in this study. All cases of infertile women with PCOS from 18 to 45 years old were analyzed in this study. All patients underwent letrozole on cycle day 3 for consecutive 5 days for up to 5 menstrual cycles. If there was a nonresponse or a poor ovulatory response occurred, the dose was increased in subsequent cycles in the either group. The maximum daily dose of letrozole was 7.5 mg. Results: The data were collected from 100 female patients. The results showed that patients who received letrozole did not exert better outcomes in neither primary endpoint, including live birth. There were not significant differences in all adverse events. All the values were expressed in mean and standard deviation. Conclusion: It is concluded that induction of ovulation with letrozole in PCOS patients is associated with limited number of mature follicles, no adverse effect on endometrial thickness or cervical mucous, and ovulation and pregnancy in a significant number of patients.

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