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A CASE-CONTROL RESEARCH TO ASSESS THE REOCCURRENCE RATE OF THYROID DYSFUNCTION DUE TO INTERFERON-α TREATMENT AMONG CHRONIC HEPATITIS C PATIENTS

Dr Hammad Sayyad Abbasi, Dr Junaid Nawaz, Dr Kiran Nayab

Objective: The point of this investigation was to survey the recurrence and kinds of thyroid dysfunction that creates amid IFN-α treatment in patients of Chronic Hepatitis C. Methods: We carried this case-control study at Mayo Hospital, Lahore from October 2017 to November 2018. The investigation was done on an aggregate of 50 patients of constant hepatitis C on recombinant IFN-α treatment. What's more 50 patients with perpetual hepatitis C, not on any antiviral treatment, were incorporated as controls. After educated assent, clinical history was gotten, physical examination was done and discoveries recorded on a pre-structured Performa. Blood testing was accomplished for thyroid profile toward the start of interferon treatment, at 12 weeks lastly at 24 weeks. Results: Thyroid dysfunction (TD) was seen in 14% (n=7) of the patients on antiviral treatment for CHC (n=50). Amongst these seven patients with TD, hypothyroidism was seen in 5 and hyperthyroidism in 2 patients. Conversely, the recurrence of thyroid dysfunction saw in charge group (n=50) was 2%. Conclusion: The recurrence of thyroid dysfunction in patients of constant hepatitis C treated with interferon approaches 14%, with hypothyroidism being the more normally watched example. Keywords: Interferon therapy, Hepatitis C, Thyroid dysfunction.

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