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TITLE:

REGULATION OF OCCURRENCE OF HEPATOCELLULAR CARCINOMA IN LIVER CIRRHOSIS RESPONDENT

AUTHORS:

Dr Ayesha Zaheer, Dr. Shahid Ali, Dr Hira Nawaz

ABSTRACT:

Background: Hepatocellular Carcinoma remains solitary of sequelae of liver cirhosis. Objective: The main objective of our research was to regulate occurrence of hepatocellular carcinoma in liver cirhosis respondents. Methodology: Our current research remained the short-term cross-sectional research, conducted at Sheikh Zayed Hospital, Rahimyar Khan from January 2018 to October 2018. In this study, cases of liver cirrhosis of either sex with age range of 41 to 81 years were selected. A total of study subjects was included in this study. The diagnosis of liver cirrhosis was made because of shrunken liver size, with or without associated portal vein dilatation and ascites. The child Pugh class was assessed by detailed clinical examination, USG and liver function tests. Hepatocellular carcinoma was labelled as yes where there was mass lesion on USG in liver with alpha fetoprotein level more than 200ng/ml. Information remained examined through using SPSS version 22. Results: In this study, 110 cases of liver cirrhosis were enrolled with mean age of 54.80±12.06 years. There were 60 (56%) males and 50 (44%) females. HCC was seen in 9 (7%) out of 110 cases. HCC was significantly high in males where it was seen in 7 (6.35%) of cases with p= 0.04. It was also significantly high in cases with age more than 54 years where it was observed in 6 (11.88%) with p= 0.07. In terms of child Pugh class, it was also significantly high in cases with class C, where all the 8 cases were seen with p= 0.002. Conclusion: Hepatocellular Carcinoma is not that uncommon and is found significantly high in males and those with child Pugh class C. Key words: HCC, Liver cirrhosis, Child Pugh class.

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